Scientists crossed domestic cats with different coat patterns, such as stripes and blotches, and tracked the inheritance of these patterns among their offspring. Genetic samples were collected and used to type various molecular markers. Results showed that specific markers were inherited by a kitten every time a given coat pattern appeared, suggesting that the marker and the gene causing the coat pattern were located in the same region of the genome. Using statistical procedures called linkage mapping, scientists determined the genomic location of two genes involved in these traits. By clarifying the inheritance of markings in one mammalian species, researchers hope to identify and characterize the implicated genes and then determine if they apply to other mammals, such as humans. The hope is that this discovery will shed new light on human skin diseases that appear to follow standardized patterns.

"Coat color and markings of animals are obvious traits that have long attracted the interest of geneticists" said Mark Johnston, Editor-in-Chief of the journal GENETICS, "and this study in cats may ultimately help us better understand the genetics behind hair and skin color in other mammals. In turn, this understanding could lead to new therapeutic strategies to correct skin problems in people."

Source: Genetics Society of America