Under the ADC collaboration agreement, MedImmune has exclusive rights to use Seattle Genetics' ADC technology with monoclonal antibodies against two targets, including EphA2. Seattle Genetics received an upfront fee and MedImmune pays ongoing technology access and material supply fees. MedImmune has also agreed to make progress-dependent milestone payments and pay royalties on net sales of ADC products. MedImmune is responsible for research, product development, manufacturing and commercialization of any products resulting from the collaboration.

Seattle Genetics is advancing a proprietary pipeline of ADC programs, including brentuximab vedotin (SGN-35), which is in an ongoing pivotal trial for relapsed or refractory Hodgkin lymphoma and a phase II trial for systemic anaplastic large cell lymphoma. Seattle Genetics is also developing a number of preclinical ADCs, including SGN-75, which the company is advancing towards a planned 2009 investigational new drug submission for CD70-positive hematologic malignancies and solid tumors.

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